Significance of Plasma Irisin, Adiponectin, and Retinol Binding Protein-4 Levels as Biomarkers for Obstructive Sleep Apnea Syndrome Severity

Objective: Obstructive sleep apnea syndrome (OSAS) is a common disorder that caused by the reduction or cessation of airflow in upper airway. Irisin, retinol-binding protein-4 (RBP-4), and adiponectin are three significant factors metabolic process human body. The objective this study was to investigate whether plasma irisin, RBP-4, levels associated with severity OSAS. Methods: According inclusion exclusion criteria, 125 patients OSAS 46 healthy, gender-matched controls were included study. classified according hypopnea index (AHI) as 14 mild cases (5 < AHI 15), 23 moderate (15 30), 88 severe (AHI > 30). measured compared between groups. Results: RBP-4 higher other groups, irisin significantly lower There negative correlation (r = −0.421; p 0.001), −0.834; positive 0.240; 0.002). −0.507; 0.001) 0.473; 0.001). As predictor OSAS, showed highest specificity (84.8%) sensitivity (92.0%). Conclusion: Circulating adiponectin, may be new biomarkers addition risk such diabetes, obesity, hypertension. When polysomnography not available, these parameters clinical data can used diagnose disease. result, an score greater than thirty should closely monitored for abnormalities.